LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer

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Linearity of intact mAb at constant dye concentration ti • linearity of 4 orders of magnitude for high sensitivity Pico protein assay 100000 10000 HT Protein Express 200 HT Pico Protein Express R 2 = 0.999 R 2 = 0.9997 Time Corrected Area 1000 100 10 1 0.01 0.1 1 10 100 1000 10000 MAb Concentration (μg/mL) 18
Low Level Impurity Detection: Non-Covalent On-Chip Staining • Impurities of as low as 1% are clearly identified • Lysozyme was spiked into the sample at 1% of total protein and was readily identified, with a S:N of 9:1 HC NGHC LC Ly 19
Page 1 and 2: LabChip GXII for High Throughput An
Page 3 and 4: LabChip GXII Applications MicroChip
Page 5 and 6: Protein Assay Workflow Crude or pur
Page 7 and 8: (1) (3) (2) Resolution Ladder Mix (
Page 9 and 10: Protein Assay Specifications Type S
Page 11 and 12: CE-SDS vs. LabChip: Non-Reducing mA
Page 13 and 14: Analysis of Subunit Vaccine Express
Page 15 and 16: LabChip GX Dependent Process Develo
Page 17: High Sensitivity: Derivatization of
Page 21 and 22: Antibody N-linked Glycans Complex M
Page 23 and 24: IgG Charged N-Glycan Types Sialylat
Page 25 and 26: Goals for HT N-Glycan Screening Ass
Page 27 and 28: HT Glycan Assay Performance Specifi
Page 29 and 30: Use of Internal Standards for Peak
Page 31 and 32: Use of Glucose Ladder For Peak Iden
Page 33 and 34: Intermediate-Assay Reproducibility
Page 35 and 36: Relative Amounts Comparison Glycan
Page 37 and 38: Acknowledgements Collaborators - Gr
Page 39: LabChip System Sampling of LabChip

LabChip GXII for High Throughput Analysis of Protein ... - PerkinElmer

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