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Full Clinical Guidelines - Community First Health Plans.

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ALGORITHM FOR TREATMENT OF MAJOR DEPRESSION WITH SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIs)<br />

Major Depressive Disorder<br />

Acute Treatment Goal: Decrease symptoms at least 50%<br />

Suggested Initial Dose of SSRI’s, Include<br />

(May need to be adjusted lower in geriatrics, debilitated, etc.)<br />

Fluvoxamine maleate 25mg po bid OR<br />

Citalopram hydrobromide 20 mg po q d OR<br />

Paroxetine hydrochloride 20 mg po q d OR<br />

Fluoxetine hydrochloride 20 mg q am OR<br />

Sertraline hydrochloride 50 mg po q am<br />

Escitalopram oxalate 10 mg q am<br />

**Practitioner should check current formulary guidelines for appropriate SSRI choices.<br />

Response After 6 weeks No Response<br />

Continuation<br />

Goal: Complete remission<br />

Duration for first episode:<br />

6-9 months before taper<br />

and D/C<br />

Maintenance<br />

(Consider use of half tablets in Fluvoxamine<br />

maleate, Paroxetine hydrochloride, Escitalopram<br />

oxalate, Citalopram hydrobromide, Fluoxetine<br />

hydrochloride or QOD in Fluoxetine hydrochloride,<br />

if appropriate)<br />

Partial Response<br />

Increase Dose<br />

Citalopram hydrobromide 20 – 40 mg po q d OR<br />

Fluvoxamine maleate 50 – 100 mg po bid OR<br />

Paroxetine hydrochloride 20 – 40 mg po q d OR<br />

Fluoxetine hydrochloride 20 – 40 mg po q d OR<br />

Sertraline hydrochloride 50 – 100 mg po q am OR<br />

Escitalopram oxalate- 20mg q am<br />

Change<br />

antidepressant or<br />

referral<br />

After 6 weeks<br />

Partial Response<br />

Change antidepressant or referral<br />

H EALTH PLANS<br />

www.cfhp.com<br />

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