Joseph Breese - Sabin Vaccine Institute
Joseph Breese - Sabin Vaccine Institute
Joseph Breese - Sabin Vaccine Institute
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Influenza vaccines: types<br />
Live attenuated vaccines<br />
• Medimmune; Russia; others in development<br />
• Delivered by nasal spray or dropper<br />
o (0.2cc divided into each nostril)<br />
• Nonpregnant, healthy individuals ages 2-49 years<br />
o Includes most HCWs<br />
o Excludes children 2-4 yrs with asthma or wheezing in last year<br />
• Potential advantages:<br />
o Ease of use<br />
o No needles<br />
o Induction of broader immunity (cell-mediated); increased<br />
heterosubtypic protection<br />
o Potentially longer-lasting immunity<br />
o Superior effectiveness in children<br />
• Limited availability
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