Joseph Breese - Sabin Vaccine Institute

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Percent Protection 100 Efficacy of inactivated influenza vaccines, 1943-1969 75 50 25 0 A(H1N1) 1943 B 1945 A(H1N1) 1950 A(H1N1) 1951 A(H1N1) 1953 B 1955 A(H1N1) 1957 A(H2N2) 1957 A(H2N2) 1958 B 1958 A(H2N2) 1960 A(H3N2) 1968 A( H3N2) 1969 Type of Virus, Year Courtesy A. Monto
Influenza <strong>Vaccine</strong>s - overview • Trivalent (H1N1, H3N2, B) – Quadrivalent fomulations now or soon licensed that include 2 B virus antigens • Annual vaccination required for optimal protection – Antigenic changes in circulating strains – <strong>Vaccine</strong>-induced antibodies wane over time • Influenza vaccine programs: – Conducted as seasonal campaigns (before local disease peaks) – (Mostly) target persons at high-risk of severe outcomes 16
Page 1 and 2: Overview of seasonal Influenza Vacc
Page 3 and 4: Seasonal Influenza Vaccines INFLUEN
Page 5: Clinical trials of inactivated vacc
Page 9 and 10: Influenza vaccines: types “Standa
Page 11 and 12: Influenza vaccines: types High-dose
Page 13 and 14: Seasonal Influenza Vaccines VACCINE
Page 15 and 16: Influenza Vaccine efficacy if IIV i
Page 17 and 18: Vaccine effectiveness: special popu
Page 19 and 20: Indirect effects of influenza vacci
Page 21 and 22: Estimates number of medically-atten
Page 23 and 24: Influenza vaccines have been part o
Page 25 and 26: Seasonal Influenza Vaccines CHALLEN
Page 27 and 28: Gaps • Most partners need educati
Page 29: THANK YOU

Joseph Breese - Sabin Vaccine Institute

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