Joseph Breese - Sabin Vaccine Institute
Joseph Breese - Sabin Vaccine Institute
Joseph Breese - Sabin Vaccine Institute
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www.cdc.gov/flu<br />
<strong>Vaccine</strong> effectiveness<br />
• Effectiveness is variable from year to year<br />
and among populations<br />
• Generally lower than routine EPI vaccines<br />
• Factors that affect true vaccine effectiveness<br />
• Antigenic relatedness between vaccine virus to circulating<br />
strains<br />
• Host factors<br />
• Age (immune responses in very young and very old)<br />
• Underlying illnesses<br />
• <strong>Vaccine</strong> type<br />
• Programmatic issues
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