Pre-Eclampsia
Pre-Eclampsia
Pre-Eclampsia
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Systemic analgesia<br />
Pethidine:<br />
prolonged half-life in the mother: 2.5-3 h<br />
prolonged half-life in the neonate: 18-23 h<br />
accumulation of active metabolites: 60 h<br />
subtle neonatal depression for days !<br />
Dr. Marc Coppens<br />
Remifentanil in obstetrics<br />
• Low dose: no efficacy<br />
• High dose: adverse effects<br />
– Maternal desaturation/sedation<br />
– FHR abnormalities<br />
• PCIA remifentanil<br />
– Volikas: 0.5 µ/kg bolus remi, lock out 5 min<br />
– Vs pethidine/meperidine/dolantine<br />
– Pain scores significantly less for remi<br />
– More respiratory depression for pethidine IV<br />
Dr. Marc Coppens<br />
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