Pre-Eclampsia
Pre-Eclampsia
Pre-Eclampsia
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Anti-hypertensive medication<br />
Vasodilation<br />
• Protect cerebral<br />
circulation<br />
Fœtal distress<br />
<strong>Pre</strong>-renal oliguria<br />
• Compromised perfusion<br />
Contracted intravascular<br />
volume<br />
<strong>Pre</strong>load ↓<br />
Venous return ↓<br />
CO ↓<br />
Dr. Marc Coppens<br />
Anti-hypertensive medications<br />
• Dihydralazine - Nepresol ®<br />
– Direct acting vasodilator > arteriolar<br />
– Loadingdose: 5 mg IV ( repeat/20 min, max 20 mg)<br />
– Maintenance dose: 1 mg/h Iv<br />
1 A or 25 mg in 50 ml NaCl 0.9 % - 2 ml/hr<br />
incompatible with gluc 5 % Side-effects:<br />
Tachycardia<br />
Hypotension<br />
Headache<br />
Long onset time !!<br />
Vomiting<br />
Epigastric pain<br />
Dr. Marc Coppens<br />
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