Pre-Eclampsia
Pre-Eclampsia
Pre-Eclampsia
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Inhalation<br />
• Chloroform: hepatic failure<br />
• Ether & cyclopropane: explosion<br />
• Halothane: headache, exhaustion, …<br />
• 1967: adverse reproductive effects<br />
• Halothane in rats: aberrant skeletal<br />
development after 12 h exposure<br />
• Fink: rats exposed to high concentrations of<br />
nitrous oxide: more skeletal abno<br />
Prolonged exposure to trace concentrations<br />
Single or repeated high dose exposure<br />
Dr. Marc Coppens<br />
Inhalational anaesthetics<br />
• No mutagenic effects ( N 2 O, E,I,D,S )<br />
• No carcinogenic effects<br />
• N 2 O is the only inhaled anaesthetic that has<br />
been convincingly shown to be directly<br />
teratogenic in experimental animals<br />
• Interference with DNA synthesis (methionine<br />
synthethase)<br />
• Consensus: any teratogenic effects caused<br />
by changes in physiology !<br />
Dr. Marc Coppens<br />
25
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