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View conference programme - The British Society for Rheumatology

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OP63 ALTERED LIPID RAFT EXPRESSION AND ASSOCIATED SIGNALLING IN T LYMPHOCYTES<br />

FROM PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE).<br />

EC Jury 1 , PS Kabouridis 2 , F Flores-Borja 2 , RA Mageed 2 , DA Isenberg 1 . 1<br />

Centre <strong>for</strong> <strong>Rheumatology</strong>,<br />

Royal Free and University College Medical School, University College London, London, United<br />

Kingdom; 2 Bone and Joint Research Unit, Bats and <strong>The</strong> London, Queen Mary’s School of Medicine<br />

and Dentistry, London, United Kingdom<br />

OP64 SEROLOGICAL INVESTIGATION OF AUTOANTIBODIES IN 577 FAMILIES WITH SYSTEMIC<br />

LUPUS ERYTHEMATOSUS.<br />

S Chadha, CA Roberton, P Charles, J Whittaker, TJ Vyse. 1 <strong>Rheumatology</strong> Section, Eric Bywaters<br />

Centre, Imperial College Faculty of Medicine, Hammersmith, London, United Kingdom; 2 Kennedy<br />

Institute of <strong>Rheumatology</strong>, Imperial College Faculty of Medicine, London, United Kingdom;<br />

3<br />

Epidemiology and Public Health, Imperial College Faculty of Medicine, St Mary’s, London, United<br />

Kingdom<br />

OP65 GENETIC DISSECTION OF BXSB LUPUS PHENOTYPE USING MICE CONGENIC<br />

FOR CHROMOSOME 1 DEMONSTRATES THAT SEPARATE INTERVALS DIRECT DIFFERENT<br />

ASPECTS OF DISEASE.<br />

MEK Haywood 1 , J Rose 1 , J Boyle 2 , AM McDermott 1 , JM Rankin 1 , S Izui 3 , MJ Walport 1 , BJ Morley 1 .<br />

1<br />

<strong>Rheumatology</strong> Section, Eric Bywaters Centre, Imperial College, London, United Kingdom;<br />

2<br />

Histopathology Department, Hammersmith Hospital, London, United Kingdom; 3 Department of<br />

Pathology, Centre Medical Universitaire, Geneva, Switzerland<br />

OP66 RECONSTITUTION OF C1q-DEFICIENCY WITH BONE MARROW DERIVED CELLS<br />

AMELIORATES THE AUTOIMMUNITY ASSOCIATED WITH C1q-DEFICIENCY.<br />

J Cortes-Hernandez 1 , L Fossati-Jimack 1 , S Izui 2 , F Petry 3 , M Loos 3 , MJ Walport 1 , M Botto 1 .<br />

1<br />

<strong>Rheumatology</strong> Section, Eric Bywaters Centre, Imperial College, London, London, United Kingdom;<br />

2<br />

Department of Pathology, University of Geneva, Geneva, Geneva, Switzerland; 3 Institute of<br />

Medical Microbiology and Hygiene, Johannes Gutenberg-University, Mainz, Mainz, Germany<br />

OP67 SEROLOGICAL CHANGES FOLLOWING B LYMPHOCYTE DEPLETION THERAPY<br />

IN SYSTEMIC LUPUS ERYTHEMATOSUS.<br />

MJ Leandro 1 , G Cambridge 1 , JCW Edwards 1 , M Teodorescu 2 , MR Ehrenstein 1 , DA Isenberg 1 .<br />

1<br />

Centre <strong>for</strong> <strong>Rheumatology</strong>, University College London, London, United Kingdom; 2 <strong>The</strong>raTest Labs,<br />

Lombard, IL, United States<br />

OP68 QUALITY OF LIFE, FUNCTIONAL STATUS AND CLINICAL FEATURES AT PRESENTATION<br />

IN POLYMYALGIA RHEUMATICA(PMR): RESULTS FROM A MULTI-CENTRE PROSPECTIVE<br />

COHORT STUDY.<br />

B Dasgupta 1 , A Hutchings 1,2 , J Hollywood 1 , D Lamping 2 , C Pease 3 , K Chakravarty 4 , B Hazleman 5 ,<br />

B Silverman 5 , E Choy 6 , DGI Scott 7 , B Bourke 8 , N Gendi 9 . 1<br />

Southend Hospital, Westcliff-on-sea,<br />

United Kingdom; 2 London School of Hygiene & Tropical Medicine, London, United Kingdom;<br />

3<br />

Leeds General Infirmary, Leeds, United Kingdom; 4 Harold Wood Hospital, Rom<strong>for</strong>d, Essex, United<br />

Kingdom; 5 Addenbrookes Hospital, Cambridge, United Kingdom; 6 King’s College London, London,<br />

United Kingdom; 7 Norfolk & Norwich Hospital, Norwich, United Kingdom; 8 St George’s Hospital,<br />

London, United Kingdom; 9 Basildon Hospital, Basildon, Essex, United Kingdom.<br />

33

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