View conference programme - The British Society for Rheumatology

227 DYSREGULATED METALLOPROTEINASE EXPRESSION IN A TRANSGENIC MOUSE
MODEL OF SCLERODERMA.
CP Denton 1 , K Lazaridis 2 , X Shiwen 1 , DJ Abraham 1 , A Chantry 2 , D Edwards 2 , CM Black 1 . 1
Centre for
Rheumatology, Royal Free and University College Medical School, Hampstead, London, United
Kingdom; 2 School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
228 GENE EXPRESSION PROFILING DELINEATES CONSTITUTIVELY ACTIVATED TARGETS OF
TGFβ IN A TRANSGENIC MODEL OF SCLERODERMA.
CP Denton, G Lindahl, VH Ong, X Shiwen, E Renzoni, DJ Abraham, CM Black. Centre for
Rheumatology, Royal Free and University College Medical School, Hampstead, London,
United Kingdom
229 DYSREGULATION OF THE EXPRESSION OF TGFβ ACCESSORY RECEPTORS IN THE
SSC FIBROBLAST.
AM Holmes, X Shi-Wen, CM Black, DJ Abraham. Rheumatology Dept., UCL-Royal Free Campus,
London, United Kingdom
230 SYNERGISTIC ENHANCEMENT OF MATRIX REMODELING IN LUNG FIBROBLASTS AFTER
CO-STIMULATION WITH ET-1 AND THROMBIN: IMPLICATIONS FOR PULMONARY FIBROSIS
IN SCLERODERMA.
X Shiwen 1 , A Leask 1 , CP Denton 1 , M Eastwood 2 , R Stratton 1 , A Holmes 1 , R duBois 3 , DJ Abraham 1 ,
CM Black 1 . 1
Rheumatology, Royal Free and University College Medical School, London, United
Kingdom; 2 Tissue Engineering Research, University of Westminster, London, United Kingdom;
3
Interstitial Lung Disease Unit, Imperial College School of Medicine, London, United Kingdom
231 THE ROLE OF TH3 (TGF-β PRODUCING) T CELLS IN SYSTEMIC SCLEROSIS.
NG Taguri, M Ponticos, DJ Abraham, CM Black. Centre for Rheumatology, Royal Free and
University College Medical School, London, United Kingdom
232 ENDOTHELIN-1 PROMOTES MYOFIBROBLAST INDUCTION THROUGH THE ETA
RECEPTOR VIA RAC/PI3 KINASE/AKT AND CONTRIBUTES TO THE CONTRACTILE PHENOTYPE
OF SCLERODERMA FIBROBLASTS.
A Leask 1 , X Shi-wen 1 , CP Denton 1 , A Holmes 1 , M Eastwood 2 , E Renzoni 3 , M Dashwood 1 , RM
duBois 3 , CM Black 1 , DJ Abraham 1 . 1
Rheumatology, Royal Free and University College Medical
School, London, United Kingdom; 2 Tissue and Engineering Research, University of Westminster,
London, United Kingdom; 3 Interstitial Lung Disease Unit, Imperial College of Medicine, London,
United Kingdom
233 MICROVASCULAR PERICYTES EXPRESS THE MESENCHYMAL STEM CELL MARKER
STRO-1 AND THE FIBROBLAST SPECIFIC ANTIGEN, THY-1.
VS Rajkumar, CM Black, DJ Abraham. Rheumatology, Royal Free & University College Medical
School, London, United Kingdom
INFLAMMATORY MUSCLE DISEASE (234 – 235)
234 INTER-RATER RELIABILITY OF TWO DISEASE ACTIVITY ASSESSMENT TOOLS IN PATIENTS
WITH IDIOPATHIC INFLAMMATORY MYOPATHY.
SM Sultan 1 , E Allen 2 , C Oddis 3 , J Vencovsky 4 , I Lundberg 5 , DA Isenberg 1 . 1
Rheumatology, University
College London, London, United Kingdom; 2 Medical Statistics, University College London, London,
United Kingdom; 3 University of Pittsburgh, Pittsburgh, United States; 4 Institute of Rheumatology,
Prague, Czech Republic; 5 Karolinska Institute, Stockholm, Sweden
235 DIFFERENCES ARE DEMONSTRATED IN THE ASSOCIATION OF MALIGNANCY BETWEEN
POLYMYOSITIS AND DERMATOMYOSITIS.
H Chinoy 1 , F Salway 2 , SJ Alan 2 , OE William 2 , CG Robert 1 . 1
Rheumatic Diseases Centre, Hope
Hospital, Salford, Lancs, United Kingdom; 2 ARC Epidemiology Unit, Stopford Building, University
of Manchester, Manchester, Lancs, United Kingdom
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