the role of adrenergic beta receptors for skin pigmentation
the role of adrenergic beta receptors for skin pigmentation
the role of adrenergic beta receptors for skin pigmentation
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ADR series knockout leads to reducing melanin<br />
production in B16 melanoma cells<br />
Effect <strong>of</strong> Specific Adrenergic Receptor Knockdown by siRNA in B16 Melanin Production<br />
Reduce Melanin Syn<strong>the</strong>sis<br />
% Knockdown <strong>of</strong> melanin production vs. control .<br />
100<br />
80<br />
60<br />
40<br />
20<br />
0<br />
-20<br />
-40<br />
-60<br />
78<br />
26 28 30<br />
ADRA1A<br />
ADRA1B<br />
ADRA1D<br />
ADRA2A<br />
25<br />
ADRA2B<br />
Over-expressed<br />
in solar<br />
lentigo<br />
69<br />
63<br />
53<br />
ADRA2C<br />
ADRB1<br />
ADRB2<br />
ADRB3<br />
-47<br />
90<br />
Tyrosinase
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