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the role of adrenergic beta receptors for skin pigmentation

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Conclusions<br />

• A series <strong>of</strong> in vitro and ex vivo studies demonstrated that<br />

Adrenergic <strong>receptors</strong> <strong>beta</strong> 1 and 2 play a key <strong>role</strong> in melanogenesis<br />

and potentially <strong>for</strong> age spot <strong>for</strong>mation<br />

• Undecylenoyl phenylalanine works effectively to suppress<br />

melanogenesis via down-regulating <strong>the</strong> <strong>adrenergic</strong> receptor <strong>beta</strong><br />

pathway in vitro<br />

• An Undecylenoyl phenylalanine moisturizer reduced <strong>the</strong><br />

appearance <strong>of</strong> facial hyperpigmented spots in a clinical study<br />

Acknowledgements<br />

• University <strong>of</strong> Cincinnati <strong>for</strong> solar lentigo samples<br />

• This work was funded by P&G Beauty & Grooming

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