the role of adrenergic beta receptors for skin pigmentation
the role of adrenergic beta receptors for skin pigmentation
the role of adrenergic beta receptors for skin pigmentation
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Beta-<strong>adrenergic</strong> receptor agonists stimulated<br />
melanin syn<strong>the</strong>sis in B16 melanoma cells<br />
• Beta <strong>adrenergic</strong> agonists (dobutamine, isoprenaline) stimulated<br />
melanin syn<strong>the</strong>sis in melanoma B16 cells, when cultured to<br />
confluency and syn<strong>the</strong>sizing sufficient melanin to detect with a<br />
simple spectrophotometric assay.<br />
Melanin Syn<strong>the</strong>sis Activity with Beta Adrenergic Agonists in B16<br />
Melanoma Cells (%control)<br />
Melanin amount [% vs. control]<br />
300<br />
250<br />
200<br />
150<br />
100<br />
50<br />
dobutamine (<strong>beta</strong>-1 agonist)<br />
Isoprenaline (<strong>beta</strong>-1&2 agonist)<br />
0<br />
0.000001 0.00001 0.0001 0.001 0.01<br />
w/v %
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