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the role of adrenergic beta receptors for skin pigmentation

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Evaluation <strong>of</strong> Undecylenoyl Phenylalanine Effect on Facial<br />

Hyper-pigmented Spots in Human Clinical Study<br />

Product<br />

Design<br />

Subject<br />

Measure<br />

• Vehicle moisturizer<br />

• 1% Undecylenoyl phenylalanine containing <strong>for</strong>mula in Vehicle<br />

• 5% Niacinamide containing <strong>for</strong>mula in Vehicle (control)<br />

• Split face, round robin design<br />

• Double blinded, left-right randomized, vehicle controlled<br />

• 8 weeks product treatment period (0, 4, 8 week visits)<br />

• Females having moderate hyperpigmented spots symmetrically on<br />

both sides <strong>of</strong> <strong>the</strong> face<br />

• 25-60 years<br />

• 110 observations per treatment<br />

• Capture facial images followed by computer image analysis <strong>for</strong> spot<br />

area and <strong>skin</strong> color

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