UROTHELIAL CARCINOMA

More documents

Recommendations

Info

POST-RADIATION PSEUDO<strong>CARCINOMA</strong>TOUS PROLIFERATION • Ulceration of mucosa ± • Pseudoinvasive nests • Lining cells – vacuolated nuclei and cytoplasm; reactive atypia • Wrapping around blood vessels • Fibrin in blood vessels • Minimal to absent mitoses • Inflammation, edema, vascular congestion, hemorrhage, hemosiderin • Post-RT-induced vascular changes or stromal changes +/-
Page 1 and 2:
Basel Seminars in Pathology Postgra
Page 3 and 4:
UPDATE ON PATHOLOGY STANDARDS FOR B
Page 5 and 6:
Molecular Pathways for Bladder Canc
Page 7:
HISTOLOGIC GRADE UROTHELIAL NEOPLAS
Page 10 and 11:
What’s New in the 2012 Consensus
Page 12 and 13:
Reporting of Bladder Cancer • Gui
Page 14 and 15:
• Seen with instrumentation with
Page 16 and 17:
Squamous Metaplasia • Should be r
Page 18 and 19:
GRADING OF UROTHELIAL LESIONS • F
Page 20 and 21:
NORMAL
Page 22 and 23:
Urothelial Dysplasia • Overall fe
Page 24 and 25:
Urothelial Dysplasia • The diagno
Page 28:
ATYPIA OF UNKNOWN SIGNIFICANCE (WHO
Page 31 and 32:
Grading of Urothelial Carcinoma •
Page 33 and 34:
Papilloma
Page 35 and 36:
PUNLMP
Page 37 and 38:
LOW GRADE
Page 39 and 40:
HIGHGRADE
Page 41 and 42:
P A P I L O M A L M P L O W G R A D
Page 43 and 44:
Courtesy R. Montironi, Italy Exophy
Page 45 and 46:
Inverted High Grade without invasio
Page 47 and 48:
Inverted Papilloma
Page 49 and 50:
Inverted PUNLMP
Page 51 and 52:
Inverted LG
Page 53 and 54:
Inverted HG
Page 55 and 56:
Inverted HG, Non Inv
Page 57 and 58:
WHO (2004) /ISUP : Prognostic Signi
Page 59 and 60:
Contributions of WHO (2004) /ISUP
Page 61 and 62:
Handling grade heterogeneity in bla
Page 63 and 64:
Grading Papillary Urothelial Neopla
Page 65:
Papillary Hyperplasia with Cytologi
Page 68 and 69:
Dysplasia with early papillary feat
Page 70 and 71:
Grading Invasive Cancer • Practic
Page 74 and 75:
• 2 types of muscle - awareness i
Page 76 and 77:
Muscularis Mucosae Muscle • Hyper
Page 78 and 79:
M. mucosae muscle patterns Typical
Page 80 and 81:
M. mucosae muscle pattern Hypertrop
Page 82 and 83:
Muscularis Propria • Several term
Page 84 and 85:
Muscle Involved by UCa, Indetermina
Page 88 and 89:
Assessment of pT2 vs. pT3 - cystect
Page 91 and 92:
Microinvasive Urothelial Carcinoma
Page 93 and 94:
Substratification or Substaging of
Page 95 and 96:
Extensive invasion
Page 97 and 98:
Retraction a mimic of vascular-lymp
Page 99 and 100:
Vascular Lymphatic Invasion (LVI)
Page 101 and 102:
2013 International Society of Urolo
Page 103 and 104:
Lymph node involvement: • Approx.
Page 105 and 106:
THE BEST BLADDER CANCER PATHOLOGY S
Page 107 and 108:
PSEUDONEOPLASTIC MIMICS OF BLADDER
Page 109 and 110:
EMPHYSEMATOUS & BULLOUS CYSTITIS
Page 113 and 114:
AMYLOIDOSIS
Page 115 and 116:
MALAKOPLAKIA
Page 117:
NORMAL PARAGANGLIONIC TISSUE
Page 123 and 124:
CIS
Page 125:
REACTIVE ATYPIA History of stones,
Page 130:
CIS REACTIVE ATYPIA
Page 134 and 135:
RADIATION ATYPIA
Page 136:
INTRAVESICAL THERAPY
Page 141: Polyoma Virus Infection • Usually
Page 149 and 150: Papillary tumor Micropapillary U Ca
Page 151 and 152: Low magnification distinction Broad
Page 153: Cystoscopic & microscopic mimic Pap
Page 158 and 159: Papillary Polypoid cystitis
Page 161 and 162: ALL THAT IS PAPILLARY BLADDER IS NO
Page 165 and 166: Bladder Biopsy Interpretation, 2nd
Page 167 and 168: TIGHTLY CLUSTERED UROTHELIUM
Page 169 and 170: TIGHTLY CLUSTERED UROTHELIUM
Page 171 and 172: U Ca. with small tubules Nephrogeni
Page 173 and 174: NEPHROGENIC ADENOMA - THE BIG MIMIC
Page 175: NEPHROGENIC ADENOMA
Page 181: NEPHROGENIC ADENOMA
Page 185 and 186: NEPHROGENIC ADENOMA Clues to benign
Page 187 and 188: FLORID REACTIVE PROLIFERATIONS norm
Page 213 and 214: Microcystic variant Cystitis cystic
Page 221 and 222: FLORID CYSTITIS GLANDULARIS WITH MU
Page 231: Pseudosarcomatous stromal reaction
Page 234 and 235: PSEUDOSARCOMATOUS MYOFIBROBLASTIC P
Page 245 and 246:
PSEUDOSARCOMATOUS MYOFIBROBLASTIC P
Page 247 and 248:
IHC IN BLADDER PATHOLOGY • Provin
Page 249 and 250:
CA in a cervical LN.
Page 251 and 252:
UROTHELIAL CARCINOMA (Prim. or Meta
Page 253:
URINARY BLADDER - IHC •Diagnosis
Page 256 and 257:
Uroplakin 3
Page 258 and 259:
Plasmacytoid U.Ca - CK20
Page 260 and 261:
S100P(commercial) • Nuclear stain
Page 262 and 263:
• Nuclear staining • lower sens
Page 264 and 265:
UROTHELIAL CA
Page 266 and 267:
PARAGANGLIOMA OF THE BLADDER - DIFF
Page 269 and 270:
CIS REACTIVE ATYPIA
Page 271 and 272:
IMMUNOHISTOCHEMISTRY IN FLAT LESION
Page 273 and 274:
NORMAL p53
Page 275 and 276:
CD-44
Page 277 and 278:
p53
Page 279 and 280:
CD-44
Page 281 and 282:
Reactive- CK20 Reactive- p53 Fig 9C
Page 283 and 284:
p53
Page 285 and 286:
CD44
Page 287 and 288:
p53 Regenerative basal cells vs. cl
Page 289 and 290:
PAGETOID CIS
Page 291 and 292:
CK20
Page 293 and 294:
p53 CK20 CD44
Page 295 and 296:
Post BCG Reactive Post BCG CIS
Page 297 and 298:
• 2 types of muscle - awareness i
Page 299 and 300:
Typical Hypertrophic-Haphazard Hype
Page 301 and 302:
Muscularis mucosae or muscularis pr
Page 303 and 304:
IMMUNOHISTOCHEMICAL MARKERS IN BLAD
Page 306 and 307:
SMA hyperplastic
Page 308 and 309:
SMA
Page 310 and 311:
Hypertrophic muscularis mucosae
Page 312 and 313:
Smoothelin - M. Mucosae
Page 314 and 315:
SMOOTHELIN IN DESMOPLASIA: NEGATIVE
Page 316:
TYPES OF MUSCULARIS PROPRIA INVASIO
Page 319:
Smoothelin SPLAYING/FRACTURING OF M
Page 322 and 323:
SMA
Page 324 and 325:
METASTATIC ADENOCARCINOMA TO THE BL
Page 328 and 329:
CK 7 CK20 CDX2 B-CATENIN
Page 330 and 331:
New Prostate Lineage Associated Mar
Page 332 and 333:
?Urothelial Carcinoma vs. ?Prostati
Page 334 and 335:
UCa GATA3 CK5/6 S100P
Page 336:
Prostatic adenocarcinoma ERG IHC Ur
Page 341 and 342:
AMACR
Page 343 and 344:
Clear cell Ca Neph. adenoma
Page 345 and 346:
U Ca. with small tubules Nephrogeni
Page 347 and 348:
NA Pax 2 S100A1 Ki67
Page 349 and 350:
U Ca Pax 2 S100A1 Ki67
Page 351 and 352:
Spindle cell lesions of bladder •
Page 353 and 354:
PSFMT/ PMP Immunohistochemistry •
Page 355 and 356:
Keratin-AE1/AE3 Desmin
Page 360 and 361:
AE1/AE3
Page 364 and 365:
SMA
Page 366 and 367:
PMP ALK 1 KERATIN AE1/3 SMA
Page 369 and 370:
Tubulointerstitial lesions Ian Robe
Page 371 and 372:
Tubules - Normal
Page 373 and 374:
Tubules - Atrophy Distribution give
Page 375 and 376:
Interstitial inflammation - tubuloi
Page 377 and 378:
Tubulointerstitial nephritis The na
Page 379 and 380:
AKI, ANCA positive, cortex - TIN, g
Page 381 and 382:
Beware TIN + red cell casts In rena
Page 383 and 384:
Male 59 years. Acute rise in creati
Page 385 and 386:
IgG4-related TIN
Page 387 and 388:
Male 70 years AKI Rigors, breathles
Page 389 and 390:
Male, 57 years. Acute renal failure
Page 391 and 392:
Ascending infection (pyelonephritis
Page 393 and 394:
Ascending infection (pyelonephritis
Page 395 and 396:
PVN can be seen in native kidneys L
Page 397 and 398:
Tubulointerstitial infiltrates in t
Page 399 and 400:
Female, 57 years. Acute renal failu
Page 401 and 402:
Haemoglobin Myoglobin Diagnosis?
Page 403 and 404:
Diagnosis?
Page 405 and 406:
Light chain tubulopathy Typically a
Page 407 and 408:
Light chain tubulopathy kappa lambd
Page 409 and 410:
Acute tubular injury in the post mo
Page 411 and 412:
Acute tubular injury in the post mo
Page 413 and 414:
Tacrolimus toxicity Diagnosis?
Page 415 and 416:
Drug-associated tubular injury Mech
Page 417 and 418:
The End
Page 419 and 420:
Session plan Renal Pathology for th
Page 421 and 422:
Tumour nephrectomy specimens Common
Page 423 and 424:
Glomerular lesions - sclerosis Scle
Page 425 and 426:
Diabetic nephropathy Earliest chang
Page 427 and 428:
Diabetic nephropathy: Linear GBM po
Page 429 and 430:
Diabetic nephropathy: Nodular scler
Page 431 and 432:
Amyloidosis
Page 433 and 434:
Amyloidosis
Page 435 and 436:
Amyloidosis Beware! Congo red may b
Page 437 and 438:
Immunotactoid Fibrillary GN
Page 439 and 440:
Light chain deposition disease
Page 441 and 442:
Light chain deposition disease
Page 443 and 444:
Idiopathic FSGS Known cause of podo
Page 445 and 446:
Focal segmental glomerulosclerosis
Page 447 and 448:
Glomerular tip lesion A manifestati
Page 449 and 450:
Glomerular lesions: proliferation M
Page 451 and 452:
IgA nephropathy Commonest glomerulo
Page 453 and 454:
Mesangial deposits have a character
Page 455 and 456:
Classification of IgA nephropathy O
Page 457 and 458:
MPGN, type I • Haematuria, protei
Page 459 and 460:
C3 glomerulopathy = Isolated C3 dep
Page 461 and 462:
Haematuria (90%), nephrotic syndrom
Page 463 and 464:
Dense deposit disease
Page 465 and 466:
Crescentic glomerulonephritis patte
Page 467 and 468:
Arteritis (approx. 20%) Renal vascu
Page 469 and 470:
Anti-GBM disease • Autoantibodies
Page 471 and 472:
Anti-GBM disease Linear IgG in glom
Page 473 and 474:
Male 46 years. Suffered from diabet
Page 475 and 476:
Male 46 years. Suffered from diabet
Page 477 and 478:
The End
Page 479 and 480:
What to do? • Download Kidney Qui
Page 481 and 482:
What to do? • Participants will s
Page 483 and 484:
PathoPic A
Page 485 and 486:
PathoPic C
Page 489 and 490:
What is your main diagnosis? 1. chr
Page 491 and 492:
What is your main diagnosis? 1. art
Page 493 and 494:
What is your main diagnosis? 1. mal
Page 495 and 496:
Solutions (I.S. Roberts)
Page 497 and 498:
B PathoPic Dg: crescentic glomerulo
Page 499 and 500:
D PathoPic Dg: no significant patho
Page 501 and 502:
Dg: amyloidosis F
Page 503 and 504:
Patterns of scarring Granular subca
Page 505 and 506:
Patterns of scarring Granular subca
Page 507 and 508:
Deep pitted cortical scars: Pattern
Page 509 and 510:
Patterns of scarring Deep pitted co
Page 511 and 512:
Patterns of scarring Segmental tran
Page 513 and 514:
Malignant hypertension A cause of a
Page 515 and 516:
Page 517 and 518:
Page 519 and 520:
Page 521 and 522:
Set 2
Page 523 and 524:
PathoPic H
Page 527 and 528:
PathoPic L
Page 529 and 530:
What is your main diagnosis? 1. col
Page 531 and 532:
What is your main diagnosis? 1. nec
Page 533 and 534:
What is your main diagnosis? 1. Ran
Page 535 and 536:
Descripition Involvement of cortex
Page 537 and 538:
Description enlargement of the kidn
Page 539 and 540:
Differential diagnosis Acute uric a
Page 541 and 542:
Differences between megalocytic IN
Page 543 and 544:
Comments to papillary necrosis
Page 545 and 546:
Prevalence of Lesions of the Renal
Page 547 and 548:
Pathogenetic types of papillary nec
Page 549 and 550:
Types of papillary necrosis: Extend
Page 551 and 552:
Phenacetin kidney Keep in mind: bla
Page 553 and 554:
Phenacetin kidney Note bone formati
Page 555 and 556:
Phenacetin kidney Capillary scleros
Page 557 and 558:
Yellow papillary necrosis Think of
Page 559 and 560:
Histological examples of papillary
Page 561 and 562:
Typical examples of papillary necro
Page 563 and 564:
Typical examples of papillary necro
Page 565 and 566:
Common Challenges in Kidney Cancer
Page 567 and 568:
ISUP Consensus Conference Vancouver
Page 570 and 571:
Image-guided biopsy. Shah et al.: H
Page 572 and 573:
Can we confidently diagnose renal o
Page 574 and 575:
„Translocation“ Type of Renal C
Page 576:
Xp11 Translocation Carcinoma in Adu
Page 579 and 580:
Clear cell-papillary RCC, sporadic
Page 581 and 582:
Should CCPRCC/CCTPRCC be Recognized
Page 583:
Do you think CCPRCC/CCTPRCC and RAT
Page 586 and 587:
DIFFERENTIAL DIAGNOSIS OF EOSINOPHI
Page 588 and 589:
What percent of a tumor needs to be
Page 590 and 591:
Assess prognosis in epithelioid AML
Page 593 and 594:
Mixed Epithelial and Stromal Tumor
Page 595 and 596:
Are Cystic Nephroma and Mixed Epith
Page 597 and 598:
Do you consider CN and MEST variati
Page 599 and 600:
Tubulocystic RCC
Page 601 and 602:
Challenges for Pathologists Diagnos
Page 603 and 604:
Sporadic Renal Cell Carcinoma Moch
Page 606:
Definition Adenoma • Tumours with
Page 609 and 610:
Survival (%) Type and Prognosis of
Page 611 and 612:
How do you subtype papillary renal
Page 613 and 614:
Hereditary Leiomyomatosis and RCC S
Page 617 and 618:
Should HLRCC be Recognized as a Dis
Page 619 and 620:
Grading of Chromophobe RCC Amin MA,
Page 621 and 622:
How should we grade papillary RCC?
Page 624 and 625:
Unlike the Skywalker family, once t
Page 626 and 627:
Survival (%) Prognostic Relevance o
Page 628 and 629:
If a Tumor Shows Sarcomatoid Morpho
Page 630 and 631:
Tumor Staging Bonsib SM. Renal lymp
Page 632 and 633:
For staging purposes, do you consid
Page 634 and 635:
Should the component of necrosis be
Page 636 and 637:
Challenges for Pathologists Diagnos
Page 638 and 639:
A proposed marker-based strategy de
Page 640 and 641:
VHL and tumor development Frew and
Page 643 and 644:
Randomised studies in the first lin
Page 645 and 646:
J Urology 180, pp. 860-866, 2008
Page 647 and 648:
Frequenz VHL Mutation in clear cell
Page 649 and 650:
Thank you
Page 652 and 653:
Potential of Needle Biopsy • Diag
Page 657 and 658:
Hereditary Renal Cancer Syndromes
Page 660 and 661:
How should HOCT be recognized? 1. S
Page 662 and 663:
Novel renal tumor types with clear
Page 664 and 665:
Renal Tumors with Clear Cytoplasm A
Page 666 and 667:
CA IX and Tumor Development Mutatio
Page 668 and 669:
Montani et al.: Am J Surg Path, May
Page 670 and 671:
Is loss of VHL sufficient to cause
Page 672 and 673:
Inside the primary cilium Receptors
Page 674 and 675:
a b c d e f Montani et al.: Am J Su
Page 676 and 677:
Additional mutation in VHL-/- cells
Page 678 and 679:
Is it Acceptable for MC-RCC to have
Page 680 and 681:
Renal Cyst in ADPKD Ki-67
Page 682 and 683:
Novel renal tumor types with clear
Page 684 and 685:
TFE3-Proteine-Expression
Page 686 and 687:
• 14/28 pts: Stage 4 • 11/13 pt
Page 689 and 690:
Translocation Carcinomas (MiTF/TFE
Page 691:
When should TFE3 and TFEB analysis
Page 694:
Clear cell-papillary RCC, sporadic
Page 698 and 699:
Differential Diagnosis of Cystic Re
Page 701 and 702:
Are Cystic Nephroma and Mixed Epith
Page 703 and 704:
smaller cysts with phyllodes glands
Page 705 and 706:
Immunohistochemistry MTSC (%) Papil
Page 707 and 708:
Which IHC marker do you think is th
Page 709 and 710:
PAX2 expression pattern in 16 spora
Page 711 and 712:
PAX2 expression and overall surviva
Page 715 and 716:
Tumors with Spindle Cell Morphology
Page 717:
Small Blue Round Cell Tumors of Kid
Page 720 and 721:
CD-99
Page 724:
CD 99 Ewing-Sarcoma/PNET
Page 728 and 729:
Synaptophysin
Page 731:
The future has arrived 82
Page 734:
VHL and Deep Sequencing • several
Page 737 and 738:
Loss of PBRM1 expression is correla
Page 739 and 740:
Cell Surface Capturing Proteomics:
Page 741:
Conclusions •Renal mass biopsy -
show all

UROTHELIAL CARCINOMA

Create successful ePaper yourself

Delete template?

Save as template?