Annual General Meeting of the Irish Thoracic Society - IJMS | Irish ...

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SESSION ONE
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ANNUAL MEETING OF THE IRISH THORACIC SOCIETY • 11 - 12 November 2005 • WESTWOOD HOUSE HOTEL, GALWAY ANNUAL MEETING OF THE IRISH THORACIC SOCIETY • 11 - 12 November 2005 • WESTWOOD HOUSE HOTEL, GALWAY
SESSION ONE
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Influence of CFTR genotype on pulmonary disease in adult
Cystic Fibrosis patients from Belfast and Dublin referral centres
Background
In referring to differences in survival between Cystic
Fibrosis (CF) patients in the Republic and Northern
Ireland, the recent Pollock Report 1 also cautions
on the interpretation of available data, citing
variation in diagnosis and coding as factors that can
complicate comparisons. Another factor that can
greatly influence survival in CF is CFTR genotype.
The aim of this study was to evaluate differences in
CFTR genotype between CF patients attending adult
referral centres in Dublin and Belfast and to assess
the influence of these differences on pulmonary
function, a major indicator of pulmonary prognosis
and survival in CF.
Methods
CFTR genotypes on 205 patients attending the
Dublin centre and 115 patients attending the Belfast
centre were collected. Pulmonary function was
assessed on all patients when clinically stable with
no evidence of acute infection.
Results
Just over half (50.4%) of the Belfast group had CFTR
Introduction
The management of acute pulmonary exacerbations
in Cystic Fibrosis has changed in recent years with
the increasing usage of home intravenous therapy.
Method
A retrospective examination of hospital admission
of patients with acute pulmonary exacerbations
of Cystic Fibrosis in 2004 was carried out. Total
admission figures were derived from the HIPE
system. A review of all home IV prescriptions during
this time was performed. This was accompanied
by review of FEV1 values and sputum culture and
sensitivity corresponding with time of exacerbation.
Results
In total there were over 300 episodes of acute
exacerbations in 2004. There were 298 admissions
to SVUH with exacerbations in 2004. In this year
131 courses of home IV’s were prescribed to 77
patients. Of these 104 were initiated and completed
genotypes that are associated with mild disease
compared only 25% of Dublin patients (p