Annual General Meeting of the Irish Thoracic Society - IJMS | Irish ...

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SESSION THREE ONE
ANNUAL MEETING OF THE IRISH THORACIC SOCIETY • 11 - 12 November 2005 • WESTWOOD HOUSE HOTEL, GALWAY
ANNUAL MEETING OF THE IRISH THORACIC SOCIETY • 11 - 12 November 2005 • WESTWOOD HOUSE HOTEL, GALWAY
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SESSION
SESSION THREE ONE
Sleep
Physiology
3.19
Endothelial-1 (ET-1) levels in obstructive sleep apnoea
(OSA) patients and effect of continuous positive airway
pressure (CPAP) treatment
3.22
Correlation between spirometry and respiratory
resistance measured by impulse oscillometry in patients
with COPD
ET-1 Is a marker for endothelial dysfunction.
There are contradictory reports about endothelial
dysfunction in OSA patients as well as levels of ET-1.
We undertook this prospective study to determine
levels of ET-1 in OSA patients and the effect of
CPAP treatment on these levels. Plasma ET-1 levels
were measured in nonapnoeic snorer males with
AHI 15 events
/hour R (N=20). Groups were matched for age,
Epworth sleepiness score, FEV1, FVC, lung volumes,
haemoglobin, platelets and cholesterol levels.
OSA patients were given treatment in the form of
3.20
CPAP for three months and plasma ET-1 levels were
repeated. We found no significant difference in
baseline plasma ET-1 levels between control and OSA
patients (P>0.05). ET-1 levels did not correlate with
AHI, minimum saturation of arterial oxygen (SAO2)
or with mean SAO2 (P.0.05 for all parameters). There
was no significant difference of baseline plasma
levels among smokers and nonsmokers (P>0.05).
In contrast, ET-1 levels decreased significantly from
baseline after treatment with CPAP. In conclusion, no
significant endothelial dysfunction in OSA patients
was detected, CPAP treatment seems to have
protective effect against Endothelial dysfunction.
The role of angiogenesis in obstructive sleep apnoea
(OSA)
A Arya, M Stack,
K O’Sullivan,
F Shanahan, CP Bredin
Dept of Respiratory
Medicine, Cork
University Hospital,
Wilton, Cork and Dept
of Statistics, University
College of Cork, Cork
Introduction
Impulse Oscillometry (IOS) is a technique that
measures Respiratory Resistance (Rrs) at several
frequencies through the interpretation of oscillatory
impulses overlapping spontaneous breathing. It is
a non-invasive, fast and easy to perform technique
that requires minimal patient cooperation.
The recorded parameters, which include Resistance
at 5Hertz (R5) and Resistance at 20Hertz (R20), can
provide valuable information for diagnosis of early
lung disease.
R5 is a measure of total respiratory resistance
including extra thoracic, central and peripheral
airways. R20 is a measure of proximal resistance
including extra thoracic and central airways.
COPD who presented for routine pulmonary function
tests were assessed. Only tests that fulfilled European
Respiratory Society criteria of acceptability and
reproducibility were included.
Results
The 15 patients (eight female/seven male) had an age
range 38 to 82 years (mean age 63 years). Traditional
spirometry outcomes, FEV1, FEF25-75, FEF25, FEF50,
and FEF75 were correlated with R5 and R20. We
found an inverse correlation between FEV1 and R5
(r=-0.867, p