View/Open - HPS Repository - Arizona State University
View/Open - HPS Repository - Arizona State University
View/Open - HPS Repository - Arizona State University
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
R25<br />
Rat cardiac muscle cell. Peter J. 5. Smith<br />
PROGRAM IN MOLECULAR PHYSIOLOGY<br />
The Program<br />
in Molecular Physiology (PMP) brings together a group of<br />
resident and visiting scientists who share common interests in the<br />
molecular bases of cellular physiology. The several laboratories making<br />
up the PMP focus on cellular plasticity and the properties of molecular<br />
transport mechanisms. A variety of experimental approaches are used<br />
ranging from molecular and biochemical methodologies, through<br />
biophysics, to advanced optical and electrochemical imaging techniques.<br />
An example of a research area spanning the independent<br />
laboratories within PMP is the role of metabolism and the mitochondrion<br />
in health and disease. How, for example, does the mitochondrion<br />
contribute to insulin secretion, heme synthesis, or channel modulation?<br />
Does the aging process, targeting metabolic disorders, contribute to<br />
reproductive and neural malfunction, degeneration, and apoptosis?<br />
In addition to our interests in basic biology the laboratories of the PMP<br />
carry on a strong tradition within the Marine Biological Laboratory<br />
resident programs for instrumentation development. The BioCurrents<br />
Research Center<br />
Institutes of Health (NCRR)<br />
a national bioengineering resource of the National<br />
has pioneered the use of electrochemical<br />
sensors to define cellular activity through monitoring conditions in the<br />
extended boundary layer.<br />
A notable characteristic of the PMP is the extensive year-round collaborative<br />
outreach to regional universities and hospitals.<br />
Members contribute<br />
to three Boston based NIH Program Project Grants in protein<br />
trafficking, diabetes, and anemia. Collaboration also allows the group to<br />
rapidly advance in areas of topical interest<br />
as with an ongoing<br />
initiative to study the molecular physiology of the multi-drug resistant<br />
transporters, players of critical interest to cancer research and our<br />
understanding of infectious diseases. Annually, the member laboratories<br />
host more than 40 national and international visitors, taking advantage<br />
of the unique combination of scientific and technical expertise concentrated<br />
at the Marine Biological Laboratory. Access is<br />
provided to<br />
experimental platforms, cutting edge imaging techniques, and a diverse<br />
array of marine models suitable for studying both basic and biomedical<br />
problems. Strong collaborative and joint research projects<br />
are also<br />
underway with other members of the resident MBL community<br />
(Staff<br />
notably the Architectural Dynamics Program and the Bay Paul Center.<br />
BioCurrents Research Center (NIH:<br />
Transport of Bioactive Molecules; Development of<br />
Electrochemical and Optical Sensors<br />
DIRECTOR/SENIOR SCIENTIST<br />
Peter J. S Smith<br />
RESEARCH ASSISTANTS<br />
Katharine Hammar<br />
Laurel Moore<br />
Richard Sanger<br />
TECHNICIAN<br />
Robert Lewis<br />
Laboratory of Peter J.5. Smith: Molecular Physiology<br />
of Transport and Sensor Development<br />
SENIOR SCIENTIST<br />
Peter J. S. Smith<br />
STAFF SCIENTIST<br />
Mark Messerli<br />
POSTDOCTORAL RESEARCHERS<br />
Abdoullah Diarra<br />
VISITING SCIENTIST<br />
Radwan Khawaled<br />
ADJUNCT SCIENTIST<br />
George Holz<br />
Laboratory of Stefan McDonough: Channel Biophysics<br />
ASSISTANT SCIENTIST<br />
Stefan McDonough<br />
Laboratory of Orian Shirihai: Molecular Physiology<br />
of Mitochondria<br />
ASSISTANT SCIENTIST<br />
Orian Shirihai<br />
POSTDOCTORAL RESEARCHERS<br />
Sarah Haigh<br />
Shana Katzman<br />
Continued...
Change language