Combinatorial Chemistry and Drug Discovery Lab Jasmine ... - haspi
Combinatorial Chemistry and Drug Discovery Lab Jasmine ... - haspi
Combinatorial Chemistry and Drug Discovery Lab Jasmine ... - haspi
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During the<br />
EXPONENTIAL or LOG<br />
PHASE bacteria are<br />
growing <strong>and</strong> dividing<br />
at the maximal rate<br />
given their genetic<br />
potential, nature of the<br />
medium <strong>and</strong> conditions<br />
under which they are<br />
growing.<br />
In the STATIONARY<br />
PHASE, the total number<br />
of viable bacteria<br />
a<br />
remains constant. This<br />
may result from a<br />
balance between cell<br />
division <strong>and</strong> cell death or<br />
cells may cease to divide<br />
while remaining<br />
metabolically active.<br />
When microorganisms are<br />
introduced into fresh culture<br />
medium usually no immediate<br />
increase in cell number occurs<br />
therefore this is referred to as<br />
the LAG PHASE.<br />
Detrimental environmental<br />
conditions such as lack of<br />
nutrients <strong>and</strong> waste buildup<br />
lead to the decline, usually<br />
logarithmic, in the number of<br />
viable cells. This is characteristic<br />
of the DEATH PHASE.<br />
What limiting factors would cause a microbial<br />
population to enter the stationary phase?