Combinatorial Chemistry and Drug Discovery Lab Jasmine ... - haspi

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Chemical Structure of the Active Compound 5-nitro-2-furaldehyde d aminoguanidine bicarbonate One of the resulting compounds created in our library of mixtures is “discovered” to have antibacterial properties. The active compound is a known antibiotic called guanofuracin which was discovered in the 1950’s and developed for both human and veterinary use.
Combinatorial Chemistry and Drug Discovery Lab Post-lab Discussion
Page 1 and 2: Combinatorial Chemistry and Drug Di
Page 3 and 4: Overview • In this lab students w
Page 5 and 6: National Science Education Standard
Page 7 and 8: Chemicals CHEMICAL VENDOR CATALOG #
Page 9 and 10: Presenter Notes Preparing Overnight
Page 11 and 12: Presenter Notes Spectrophotometer 1
Page 13 and 14: Instructor Notes If mixtures are no
Page 15 and 16: Tips for handling E.coli: Lab Safet
Page 17 and 18: During the EXPONENTIAL or LOG PHASE
Page 19 and 20: Ouchterlony Test •A double diffus
Page 21 and 22: Label transfer pipettes 1. Label 6
Page 23 and 24: Label Petri dishes M1 M2 M4 M5 A#B1
Page 25 and 26: Prepare mixtures (libraries) 1. Mak
Page 27 and 28: Incubate at 37ºC or store at room
Page 29 and 30: Chemical Structures of Synthesized
Page 31 and 32: Data Analysis - + = no inhibition o
Page 33 and 34: Extension: Kirby-Bauer Test Determi
Page 35 and 36: Extension: Zone Size Interpretive C
Page 37: Results at Room Temperature
Page 41 and 42: Three Major Classes of Antibacteria
Page 44 and 45: Antibacterial Sites of Action
Page 46: Great Job Jasmine Erfe!

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