Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
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<strong>Metabolic</strong> <strong>and</strong> <strong>Biochemical</strong> <strong>Alterations</strong><br />
<strong>in</strong> <strong>Alzheimer</strong> <strong>Disease</strong>: <strong>Facts</strong> <strong>and</strong> Fictions<br />
Prof. Mark A. Smith<br />
Oxidative damage directly correlates<br />
with mtDNA<br />
mtDNA<br />
(optical<br />
density<br />
X100)<br />
8.0<br />
7.0<br />
6.0<br />
5.0<br />
4.0<br />
3.0<br />
2.0<br />
1.0<br />
0.0<br />
0 2 4<br />
R 2 = 0.8374<br />
6 8 10 12 14 16<br />
8OHG (optical density X100)<br />
28<br />
A<br />
Abnormal mitochondrial distribution<br />
<strong>in</strong> AD bra<strong>in</strong>s<br />
B<br />
C<br />
E<br />
J Neurosci., 29, 9090-103 (2009)<br />
29<br />
PET SCAN-profound metabolic<br />
decrease as an early <strong>in</strong>dicator of AD<br />
Control<br />
<strong>Alzheimer</strong><br />
30<br />
The screen versions of these slides have full details of copyright <strong>and</strong> acknowledgements<br />
10
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