Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
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<strong>Metabolic</strong> <strong>and</strong> <strong>Biochemical</strong> <strong>Alterations</strong><br />
<strong>in</strong> <strong>Alzheimer</strong> <strong>Disease</strong>: <strong>Facts</strong> <strong>and</strong> Fictions<br />
Prof. Mark A. Smith<br />
Selective neurodegeneration<br />
<strong>in</strong> CaMKII-MYC mice<br />
MYC-ON<br />
MYC-OFF<br />
Am J Pathol., 174, 891-7 (2009)<br />
52<br />
Selective neurodegeneration<br />
<strong>in</strong> CaMKII-MYC mice (2)<br />
TUNEL assay<br />
GFAP<br />
MYC-ON<br />
Am J Pathol., 174, 891-7 (2009)<br />
MYC-OFF<br />
53<br />
Cognitive deficits <strong>in</strong> CaMKII-MYC mice<br />
The Morris water maze (WMM)<br />
T-maze<br />
Escape latency<br />
(distance moved)<br />
850<br />
810<br />
770<br />
730<br />
690<br />
650<br />
On Off<br />
1 2 3<br />
Tran<strong>in</strong>g (day)<br />
40<br />
35<br />
On<br />
30<br />
25<br />
20<br />
15<br />
10<br />
% time <strong>in</strong> target quadrant<br />
Am J Pathol., 174, 891-7 (2009)<br />
Off<br />
54<br />
The screen versions of these slides have full details of copyright <strong>and</strong> acknowledgements<br />
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