Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
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<strong>Metabolic</strong> <strong>and</strong> <strong>Biochemical</strong> <strong>Alterations</strong><br />
<strong>in</strong> <strong>Alzheimer</strong> <strong>Disease</strong>: <strong>Facts</strong> <strong>and</strong> Fictions<br />
Prof. Mark A. Smith<br />
Menopause<br />
APP/PS1<br />
Obesity<br />
Aβ/tau<br />
Cholesterol<br />
Oxidative<br />
stress<br />
APOE<br />
Ag<strong>in</strong>g<br />
STOP<br />
Cytochrome C/<br />
cell death<br />
Ca 2+<br />
buffer<strong>in</strong>g<br />
Oxidative<br />
stress<br />
Redox<br />
metals<br />
Synaptic<br />
dysfunction<br />
<strong>Metabolic</strong><br />
alterations<br />
64<br />
“The way to get th<strong>in</strong>gs done<br />
is not to m<strong>in</strong>d who gets the credit for do<strong>in</strong>g them”<br />
Benjam<strong>in</strong> Jowett (1817-1893), British theologian <strong>and</strong> classicist<br />
65<br />
Collaborators<br />
Case Western Reserve Univ. Centro Biologia Molecular,<br />
• George Perry (Pathology) Madrid<br />
• Lawrence M. Sayre (Chemistry) • Jesús Avila<br />
• Xiongwei Zhu (Pathology) Harvard University<br />
• Gemma Casadesus<br />
• Ashley Bush<br />
(Neurosciences)<br />
Johns Hopk<strong>in</strong>s University<br />
• Hyoung-gon-Lee (Pathology) • Donald Price<br />
• Robert P. Friedl<strong>and</strong><br />
University of Barcelona<br />
(Neurology)<br />
• Rudy Castellani (Pathology)<br />
• Luke Szweda<br />
(Physiology/Biophysics)<br />
• Alfred Rimm (Epidemiology)<br />
• Bruce Lamb (Genetics)<br />
• Grace Petot (Nutrition)<br />
• Paul Carey (Biochemistry)<br />
Asahikawa Medical College<br />
• Akihiko Nunomura<br />
• Shigeru Chiba<br />
• Merce Pallas<br />
• Toni Cam<strong>in</strong>s<br />
Voyager Pharmaceuticals<br />
• Richard Bowen<br />
Columbia University<br />
• Shi-Du Yan<br />
• David Stern<br />
Takeda Chemical Company<br />
•Keisuke Hirai<br />
Thomas Jefferson University<br />
• Hilary Koprowski<br />
Tohoku University<br />
School of Medic<strong>in</strong>e<br />
• Atsushi Takeda<br />
University of California<br />
San Diego<br />
• Donald Clevel<strong>and</strong><br />
University of South Alabama<br />
• Miguel A. Pappolla<br />
University of Genova<br />
• Massimo Tabaton<br />
66<br />
The screen versions of these slides have full details of copyright <strong>and</strong> acknowledgements<br />
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