Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
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<strong>Metabolic</strong> <strong>and</strong> <strong>Biochemical</strong> <strong>Alterations</strong><br />
<strong>in</strong> <strong>Alzheimer</strong> <strong>Disease</strong>: <strong>Facts</strong> <strong>and</strong> Fictions<br />
Prof. Mark A. Smith<br />
Amyloid-targeted approaches<br />
have been unsuccessful (so far…ever?)<br />
Reasons: Too late! Not strong enough! Wrong target!<br />
The American Journal of Geriatric Pharmacotherapy (2009) M.N. Sabbagh<br />
16<br />
Is amyloid an antioxidant?<br />
Neuronal oxidative stress decreases<br />
follow<strong>in</strong>g amyloid-β deposition<br />
R=-0.97, p
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