Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
Metabolic and Biochemical Alterations in Alzheimer Disease: Facts ...
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<strong>Metabolic</strong> <strong>and</strong> <strong>Biochemical</strong> <strong>Alterations</strong><br />
<strong>in</strong> <strong>Alzheimer</strong> <strong>Disease</strong>: <strong>Facts</strong> <strong>and</strong> Fictions<br />
Prof. Mark A. Smith<br />
What causes selective neuronal loss <strong>in</strong> AD?<br />
• Almost every physiological/pathological mechanism<br />
that a cell can elicit has been implicated!<br />
• And most are probably <strong>in</strong>volved…<br />
• At some po<strong>in</strong>t…<br />
4<br />
The usual suspects<br />
5<br />
Proposed chronology of changes <strong>in</strong> AD<br />
Tauist <strong>and</strong> BAPtist<br />
Tau phosphorylation<br />
[Neurofibrillary tangles]<br />
Amyloid-β deposition<br />
[Senile plaque]<br />
Amyloid-β deposition<br />
[Senile paque]<br />
Neuro nal death:<br />
dem mentia<br />
Tau phosphorylation<br />
[Neurofibrillary tangles]<br />
6<br />
The screen versions of these slides have full details of copyright <strong>and</strong> acknowledgements<br />
2
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