Role of glycated LDL in diabetic atherosclerosis
Role of glycated LDL in diabetic atherosclerosis
Role of glycated LDL in diabetic atherosclerosis
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Naturally occurr<strong>in</strong>g atherogenic modifications <strong>of</strong> lipoprote<strong>in</strong>s <strong>in</strong>clude oxidation, glycation<br />
& glycoxidation<br />
glycoxidation<br />
Modified <strong>LDL</strong> is considered to be a risk factor for the development and progression <strong>of</strong> <strong>atherosclerosis</strong>.<br />
<strong>glycated</strong> <strong>LDL</strong> is present <strong>in</strong> the circulation at much higher concentration than oxidized<br />
<strong>LDL</strong>, even <strong>in</strong> non-<strong>diabetic</strong> people & can stimulate foam cell formation.<br />
Witztum JL, Ste<strong>in</strong>berg D. <strong>Role</strong> <strong>of</strong> oxidized low density lipoprote<strong>in</strong> <strong>in</strong> atherogenesis. J Cl<strong>in</strong> Invest 1991;<br />
88:1785–1792.& Tanaka, Akira Atherosclerosis, Volume 52 Spr<strong>in</strong>ger Protocols – Jan 1, 2001
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