Role of glycated LDL in diabetic atherosclerosis

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It was suggested that the earliest event is glycation of LDL, whilst oxidative events (glycoxidation or direct oxidation of lipid or proteins) only occur at later time points. This may facilitate the formation of foam cells and the vascular complications of diabetes Eur J Biochem. 2003 Sep;270(17):3572-82. Glycation and glycoxidation of low-density lipoproteins by glucose and lowmolecular mass aldehydes. Formation of modified and oxidized particles. Knott HM, Brown BE, Davies MJ, Dean RT.
Factors Influencing Plasma Level of Glycated apoB • Plasma glyc-apoB correlated with SD-LDL-apoB ( p < 0.0001 in DM & , p < 0.001 in MS), but not with HbA1c. Thus SD-LDL concentration is a stronger determinant of plasma glyc-apoB than glycaemia. Younis NN, Soran H, Sharma R, et al. Small-dense LDL and LDL glycation in metabolic syndrome and in statin-treated and nonstatin-treated type 2 diabetes. Diab Vasc Dis Res 2010; 7:289–295
Page 1 and 2: Prof. Sanaa Gazareen, MD Head of Di
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Role of glycated LDL in diabetic atherosclerosis

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