Role of glycated LDL in diabetic atherosclerosis
Role of glycated LDL in diabetic atherosclerosis
Role of glycated LDL in diabetic atherosclerosis
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Glycated Vs Oxidized <strong>LDL</strong> <strong>in</strong> non <strong>diabetic</strong> subjects<br />
Oxidized <strong>LDL</strong><br />
• does not exist <strong>in</strong> the<br />
circulation because <strong>of</strong> the<br />
presence <strong>of</strong> many<br />
antioxidiz<strong>in</strong>g agents .<br />
• <strong>LDL</strong> cannot be oxidized<br />
until it has entered the<br />
arterial wall from the<br />
circulation<br />
Glycated <strong>LDL</strong><br />
• The only modified <strong>LDL</strong> that<br />
exists <strong>in</strong> the circulation . It<br />
has been shown to be more<br />
easily oxidized than native<br />
<strong>LDL</strong><br />
• Thus glycation <strong>of</strong> <strong>LDL</strong> may<br />
be the <strong>in</strong>itial step <strong>in</strong> the<br />
development <strong>of</strong><br />
<strong>atherosclerosis</strong>.<br />
Tanaka, Akira : Atherosclerosis, Volume 52 Spr<strong>in</strong>ger Protocols – Jan 1,<br />
2001
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