Erik Lindahl

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Partitioning • Consider transfer of hydrocarbon to H 2 O • Concentrations (X) iso. probabilities • Count per mol, so R instead of k • X∝exp{-G/RT} • ∆Gliq->aq = -RT ln (Xaq/Xliq) • Free energies can be measured in lab!
Reality Check • Chapters 3 & 4 in “Protein physics” • Amino acids determine protein structure • Electrostatics & hydrogen bonds • Van der Waals / Lennard-Jones • Energy Landscapes • The Boltzmann Distribution • Free Energy • Do you understand entropy yet?
Page 1: Protein Physics 2012 Lecture 2, Jan
Page 6 and 7: Natural amino acids
Page 9 and 10: α R β α L
Page 11 and 12: Outline today • More on interacti
Page 13 and 14: Semi-Empiric Modeling • Use simpl
Page 15 and 16: Bond stretching • Vibration aroun
Page 17 and 18: Torsions/dihedrals Frequently calle
Page 19 and 20: Nonbonded interactions Packing effe
Page 21 and 22: Lennard-Jones • Simpler form than
Page 23 and 24: Hydrophobic effect
Page 25: The Boltzmann Distribution ⇢ / e
Page 28 and 29: Formulating Boltzmann • Clapeyron
Page 30 and 31: Which shape is best energy-wise? Vo
Page 32 and 33: Free Energy • Use V=exp{ln(V)}
Page 34 and 35: How many states does this correspon
Page 36 and 37: Phase Transitions Explained • Sys

Erik Lindahl

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