Pharmacology
Pharmacology
Pharmacology
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Drugs Produce More Than One Effect<br />
Drugs Produce More Than One Effect<br />
% Response<br />
100<br />
75<br />
50<br />
25<br />
constipation<br />
antitusive<br />
analgesia<br />
resp. depression<br />
death<br />
% Response<br />
100<br />
75<br />
50<br />
25<br />
Therapeutic Index “window”<br />
LD 50<br />
ED 50<br />
=<br />
50<br />
2<br />
= 25<br />
analgesia<br />
death<br />
0<br />
0.001 0.01 1.0 10.0<br />
100.0 1000.0<br />
0<br />
0.001 0.01 1.0 10.0<br />
100.0 1000.0<br />
Log Morphine (mg/kg)<br />
ED 50 (2mg/kg)<br />
LD 50 (50mg/kg)<br />
Log Morphine (mg/kg)<br />
Response According to Age Sex Health<br />
% Response<br />
100<br />
80<br />
60<br />
40<br />
20<br />
Teenager Female Lance Armstrong<br />
Middle Male Todd Vanderah Age<br />
Elderly Dick Cheney<br />
0<br />
1 3 10 30 100 300<br />
Log [Drug]
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