Pharmacology

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Receptors The majority of all Receptors are proteins Receptors bind with drugs & bring about change in cell function Evidence for Receptors 1. Extreme Potency/Efficacy of Drugs 2. Chemical Selectivity (i.e., similar molecules produce similar effects) Evidence for Receptors 1. Extreme Potency/Efficacy of Some Drugs 2. Chemical Selectivity (i.e., similar molecules produce similar effects) 3. Stereoselectivity
L-Epinephrine D-Epinephrine L-Epinephrine D-Epinephrine OH H H CH 3 OH OH H CH 3 OH C C N OH H H OH C C N H H H Stereo-Selectivity OH H H CH 3 OH OH H CH 3 OH C C N OH C C N OH H H H H H Intracellular Effects Evidence for Receptors Targets for Drug Action 1. Extreme Potency/Efficacy of Some Drugs 2. Chemical Selectivity (i.e., similar molecules produce similar effects) 3. Stereoselectivity 4. Competitive Antagonists 5. Cloning and Expression of Receptors
Page 1 and 2: Pharmacology from the ancient Greek
Page 3: Dose Response Lock & Key Theory of
Page 7 and 8: G-protein Coupled Receptors G-prote
Page 9 and 10: Tyrosine Kinase Receptors Kinase ca
Page 11 and 12: Quantal Dose Response Curve Graded
Page 13 and 14: Shift in Potency No loss of Efficac
Page 15 and 16: Review Agonists: Affinity, Selectiv
Page 17 and 18: C & Aδ Fibers Pain Pathways Somato
Page 19 and 20: Peripheral Nociceptor Activation
Page 21 and 22: Spinothalamic Projection to Thalamu
Page 23 and 24: δ Opioid Receptor κ Opioid Recept
Page 25 and 26: Addiction Liability Dopaminergic Di
Page 27 and 28: Fentanyl and Analogues Meperidine
Page 29: Naloxone Naltrexone • Prototypica

Pharmacology

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