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Pharmacology

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C and Aδ Nociceptor Mediated Pain<br />

C-fiber<br />

Touch fibers<br />

DRG<br />

Dorsal<br />

Columns<br />

Spinothalamic<br />

Tract<br />

Periphery<br />

Spinal Cord<br />

Pain Fibers<br />

Aδ fiber<br />

Lisauer’s tract<br />

I<br />

Pain<br />

intensity<br />

First<br />

pain<br />

Second<br />

pain<br />

laminae<br />

II<br />

IV<br />

V<br />

Time<br />

Ventral<br />

Roots<br />

Burn<br />

Spinothalamic<br />

Projection to<br />

Thalamus<br />

Opioids Inhibit Noxious Input<br />

Nociceptive<br />

Input<br />

Flare<br />

ENK<br />

Ca ++<br />

Substantia<br />

gelatinosa<br />

Spinal<br />

Cord<br />

μ Opioid Receptors<br />

Pain Transmitters:<br />

Glutamate<br />

Substance P<br />

Dorsal Horn,<br />

Spinal Cord<br />

EPSP

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