Pharmacology
Pharmacology
Pharmacology
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C & Aδ Fibers<br />
Pain Pathways<br />
Somatosensory<br />
Cortex<br />
Thalamus<br />
From<br />
Brain<br />
To<br />
Brain<br />
Spinal<br />
Cord<br />
Neural Steps in the Processing of Pain Signals<br />
1. Transduction - Noxious stimuli → electrical signals<br />
2. Transmission - Neural events from the periphery to the<br />
cortex<br />
3. Modulation - Nervous system can selectively inhibit or<br />
enhance pain signals<br />
4. Perception - subjective interpretation by the cortex<br />
Sensory component<br />
Affective component<br />
Nociceptive Transmission Pathway<br />
Sensory<br />
Receptor Periphery CNS<br />
Nociceptors:<br />
• C-polymodal<br />
small, non-myelinated<br />
• Aδ-mechanical<br />
thermal<br />
Medium, thinly-myelinated<br />
Spinal<br />
cord<br />
DRG<br />
Thalamus
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