Gracial ProdMonograph_cover - epgonline.org

Pharmacodynamics
In an ultrasound study, Van der Vange et al (1988)
investigated the effects of Gracial on ovarian activity, utilizing
a "standard" 21- (7+14) day regimen. They found that the low
progestogen dosage in the combiphasic regimen permitted
more ovarian activity than did a conventional 30 µg EE
monophasic pill containing DSG. However there was, in every
case, complete inhibition of ovulation.
Jung-Hoffman et al (1992) demonstrated that Gracial caused
significant suppression of LH and FSH levels. This was
confirmed by Kuhl et al (1993) (Figure 8) who demonstrated a
significant reduction in gonadotrophin and a profound
suppression of estradiol and progesterone levels, indicating
impairment of follicular development and reliable inhibition of
ovulation.
Conclusion
Pharmacodynamic studies have demonstrated that Gracial
suppresses gonadotrophin secretion and reliability inhibits
ovulation.
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