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Gracial ProdMonograph_cover - epgonline.org

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Pharmacodynamics<br />

mIU/ml<br />

7<br />

6<br />

5<br />

4<br />

3<br />

2<br />

1<br />

0<br />

pg/ml<br />

160<br />

140<br />

120<br />

100<br />

80<br />

60<br />

40<br />

20<br />

0<br />

ng/ml<br />

10<br />

9<br />

8<br />

7<br />

6<br />

5<br />

4<br />

3<br />

2<br />

1<br />

0<br />

Pretreatment<br />

cycle<br />

Pretreatment<br />

cycle<br />

Pretreatment<br />

cycle<br />

= LH<br />

= FSH<br />

Cycle 1 Cycle 3 Cycle 6<br />

LH and FSH<br />

Cycle 1 Cycle 3 Cycle 6<br />

Estradiol<br />

Cycle 1 Cycle 3 Cycle 6<br />

Progesterone<br />

Posttreatment<br />

cycle<br />

Posttreatment<br />

cycle<br />

Posttreatment<br />

cycle<br />

Fig. 8: Changes in FSH, LH, estradiol and<br />

progesterone serum concentrations on day<br />

21–24 of the pretreatment cycle, day 18–22<br />

of the first, third and sixth treatment cycle<br />

and day 21–24 of the post-treatment cycle<br />

Kuhl et al 1993<br />

14

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