Gracial ProdMonograph_cover - epgonline.org

Gracial and mild to moderate acne
Number and
severity of acne
lesions reduced
Recently, the effects of Gracial on acne were again compared
with those of an OC preparation containing ethinylestradiol and
cyproterone acetate (2.0 mg cyproterone acetate/35 µg EE)
(Melief 2000). The study (in which 172 women were randomized
to either treatment) found that Gracial progressively reduced
the number and severity of acne lesions during the six cycles of
treatment. In both groups, the majority of women with severe
acne shifted to a less severe acne category (Figure 14). The
efficacy of Gracial was comparable to the preparation containing
the antiandrogen cyproterone acetate and no statistically
significant differences were observed between the two groups.
%
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90
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0
%
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A
0 3 6 0 3 6
Combiphasic EE/DSG
EE35/CPA
B
0 3 6 0 3 6
Combiphasic EE/DSG
EE35/CPA
Severe Moderate Mild No acne
Fig. 14: Objective (A) and subjective (B) classification
of severity of acne at pretreatment, Cycle 3
and Cycle 6
25
Melief 2000