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Vasculitis - Langford.pdf - AInotes

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Urticarial <strong>Vasculitis</strong><br />

Consists of two key elements:<br />

• Clinical manifestations of urticaria<br />

• Histology: leukocytoclastic vasculitis, , largely involving postcapillary venules<br />

Skin lesions differ from common urticaria:<br />

• Wheals may have a central dark or red appearance<br />

• Lesions last > 24 hours<br />

• Often resolve with residual hyperpigmentation<br />

• Typically painful with a burning/stinging sensation<br />

• Pruritis less common than true urticaria<br />

Can be associated with systemic features<br />

• Musculoskeletal (arthralgias(<br />

arthralgias, , arthritis)<br />

• Pulmonary (COPD)<br />

• Renal<br />

• GI

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