Vasculitis - Langford.pdf - AInotes

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Urticarial Vasculitis Hypocomplementemic Urticarial Vasculitis Syndrome (HUVS) Diagnostic criteria (Schwartz et al. Mayo Clin Proc 1982;57:231) Major criteria (both must be present) • Urticaria for more than 6 months • Hypocomplementemia Minor criteria (must have 2 or more) • Venulitis of the dermis (established via biopsy) • Arthralgia or arthritis • Mild glomerulonephritis • Uveitis or episcleritis • Recurrent abdominal pain • Positive C1q precipitin test with an associated suppressed C1q level
Urticarial Vasculitis Treatment Treat underlying disease if one is present For cutaneous lesions, variable efficacy: • Prednisone • Hydroxychoroquine • Dapsone • Colchicine For severe systemic disease: • Systemic immunosuppression may be required For HUVS • Treatment as above for cutaneous or systemic disease • Some series have shown stabilization with cyclosporin • COPD often presents significant challenges
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Vasculitis Carol A. Langford, MD, M
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CME Disclosure Statements Carol A.
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Vasculitis = Inflammation of the Bl
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Example Clinical Consequence Vein V
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Vein Venule Capillary Arteriole Art
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