Organic Chemistry Semester 1 LABORATORY MANUAL - Moravian ...

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Part V. Experiments 40 Fall 2010 1 H-NMR Spectrum Experiment 7 Part B Week 2 How Do <strong>Organic</strong> Compounds Interact with Light and Magnetic Fields and What Structural Information Can We Obtain from the Results 13 C-NMR Spectrum B. Pre-lab Preparation Assignment: 1. Read: This handout 2. Work Through: Lab Manual Part V. Appendix E3-E5. 4. Complete electronic Prelab-2 Questions (course website) by 8:00 PM, Monday, November 15 on the Course Blackboard Site as explained on the Course Information page. 5. Consider possible claims and warrants for the QOW (See below) 6. In your lab notebook: (See Lab Manual pp. 15-17 for format.) a. Enter the title of the experiment, name of group members and QOW on the appropriate first left-hand page. b. Up-date the Table of Contents. 7. Bring your notebook and your initial claims and warrants concerning the QOW to the AM lab discussion period on Tuesday, November 16. Be sure to also bring your lab manual. B. Objective: To gain experience with analyzing NMR spectral data to determine the structure of organic compounds. C. Question of the Week: What structural information can be obtained from NMR spectra without chemical shift assignments D. Key Terms/concepts/techniques: • Nuclear Magnetic Resonance Spectroscopy • Number of Absorptions • Signal Integration
Part V. Techniques and Theory Appendix A1 Acid-Base Solubility Part V. Techniques and Theory Appendix A. Classification of unknown compounds from their solubilities in aqueous media: Observations: 1. Solubility in Water Most organic compounds are insoluble in water, however, polar compounds that have no more than about 5 carbon atoms for every oxygen, nitrogen or sulfur atom are usually at least slightly soluble in water. If the compound does dissolve, the pH of the resulting solution will suggest whether the compound is strongly acidic (pH 9) or essentially neutral (pH ≥4 and ≤9). 2. Solubility in Base (1M NaOH) Acidic compounds that are insoluble in water are generally more soluble in 1M NaOH than they are in water. 3. Solubility in Acid (1M HCl) Basic compounds that are insoluble in water are generally more soluble in 1M HCl than they are in water. Water is a strongly polar molecule that forms strong and randomly distributed hydrogen bonds (H-bonds). Explanations: Theory: In the process of dissolving a solute, “holes” in water’s H-bonded structure must be created. Creation of the holes disrupts some of water’s strong hydrogen bonds and reduces the randomness of the remaining ones. Thus, dissolving solutes will raise the free energy (ΔG>1) of water (ΔH>1 & ΔS
Page 1: MORAVIAN COLLEGE CHEMISTRY DEPARTME
Page 4 and 5: Table of Contents (continued) 2 PAR
Page 6 and 7: I. Introduction 4 Fall 2010 Assignm
Page 8 and 9: I. Introduction 6 Fall 2010 Assignm
Page 10 and 11: Part I. Introduction 8 Fall 2010 La
Page 12 and 13: Part I. Introduction 10 Fall 2010 D
Page 14 and 15: Part II. Lab Rules and Regulations
Page 16 and 17: Part II. Lab Rules and Regulations
Page 18 and 19: III Laboratory Records & Report For
Page 24 and 25: Part V. Experiments 22 Fall 2010 Pa
Page 26 and 27: Part V. Experiments 24 Fall 2010 Ex
Page 28 and 29: Part V. Experiments 26 Fall 2010 H
Page 30 and 31: Part V. Experiments 28 Fall 2010 E.
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Page 40 and 41: Part V. Experiments 38 Fall 2010
Page 45 and 46: Part V. Techniques and Theory Appen
Page 57 and 58: c Part V. Techniques and Theory App
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Page 64 and 65: Nuclear Magnetic Resonance Appendix
Page 84: Nuclear Magnetic Resonance Appendix

Organic Chemistry Semester 1 LABORATORY MANUAL - Moravian ...

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