Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
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Step 3. Consider the age of the child<br />
• Predictability based on child’s age and age-specific<br />
exposures<br />
– Newborn period (L. monocytogenes, GBS, E. coli)<br />
– Developmental maturity of immune system provides<br />
improved recognition of polysaccharide-encapsulated<br />
pathogens (S. pneumoniae, Hib) as <strong>in</strong>fants approach 3 y/o.<br />
– Group childcare exposures <strong>in</strong> young <strong>in</strong>fants are l<strong>in</strong>ked to<br />
carriage of, and <strong>in</strong>fection by, antibiotic-resistant stra<strong>in</strong>s of<br />
S. pneumoniae<br />
– School-related exposure to S. pyogenes and older children<br />
to atypical pathogens (low <strong>in</strong> young <strong>in</strong>fants)<br />
– Adolescent exposure to STIs
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