Principles in antimicrobial therapy - Pediatric Infectious Disease ...

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Time vs concentration-dependent antibiotics • PD of antibiotics are based on: – 1. kinetics of bacterial killing – 2. post-antibiotic effect (PAE) – 3. post-antibiotic leukocyte enhancing effect (PALE) – 4. inoculum effect
Time vs concentration-dependent antibiotics • Concentration-dependent antibiotics – Exhibit a concentration-dependent killing: • The higher the concentration of the drug, the greater the bactericidal effect – PAE: the time period after an exposure to and removal of an antimicrobial agents during which inhibition of bacterial growth persists – In vivo PALE: enhanced leukocyte phagocytosis and intracellular killing of bacterial during the drug-free period
Page 1 and 2: Principles in antimicrobial therapy
Page 3 and 4: Is there anything beyond BE? • Fo
Page 5 and 6: Objectives • 1. Review the basic
Page 7 and 8: Selecting Optimal Antimicrobial The
Page 9 and 10: Acute Otitis Media Macrolides or b-
Page 11 and 12: Step 3. Consider the age of the chi
Page 13 and 14: Step 5. Consider antibiotic suscept
Page 15 and 16: Enteric Patogens 90 80 Percent Resi
Page 17 and 18: Staphlococci and Enterococci % Resi
Page 19 and 20: Gram negative, non-fermentative bac
Page 21 and 22: Step 6. Consider PK/PD properties o
Page 23 and 24: PD antibacterial effect of antimicr
Page 25 and 26: PD antibacterial effect of antimicr
Page 27 and 28: PK/PD basis of optimal antibiotic t
Page 29: Schematogram of sites of action for
Page 33 and 34: Time vs concentration-dependent ant
Page 35 and 36: Time-dependent vs. Concentration-de
Page 37 and 38: Step 7. Consider target attainment
Page 39 and 40: Step 7. Consider target attainment
Page 41 and 42: Step 8. Separate empiric and defini
Page 43 and 44: Step 9. Special considerations •
Page 45 and 46: Take home message • The armamenta

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