Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
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Select<strong>in</strong>g Optimal Antimicrobial Therapy<br />
(adapted from <strong>Pr<strong>in</strong>ciples</strong> of Anti-<strong>in</strong>fective Therapy by John Bradley and Sarah Long <strong>in</strong><br />
<strong>Pr<strong>in</strong>ciples</strong> & Practice of <strong>Pediatric</strong> <strong>Infectious</strong> <strong>Disease</strong>s)<br />
Questions pert<strong>in</strong>ent to choos<strong>in</strong>g <strong>antimicrobial</strong> <strong>therapy</strong> appropriately<br />
6. What special pharmacok<strong>in</strong>etic and pharmacodynamic properties of a<br />
therapeutic agent are important regard<strong>in</strong>g the site of the <strong>in</strong>fection host?<br />
7. For any given <strong>in</strong>fection site, what percent of children require effective<br />
<strong>antimicrobial</strong> <strong>therapy</strong> with agents first selected for treatment? Bacterial<br />
men<strong>in</strong>gitis requires 100%, whereas 75% may be acceptable for impetigo.<br />
8. What empiric <strong>therapy</strong> and what def<strong>in</strong>itive <strong>therapy</strong> would be optimal?<br />
Agents with a broad spectrum of activity may be appropriate for empiric<br />
<strong>therapy</strong>, whereas those with a narrow spectrum of activity are preferred for<br />
def<strong>in</strong>itive <strong>therapy</strong>.<br />
9. What special considerations exist regard<strong>in</strong>g drug allergy, drug <strong>in</strong>teraction,<br />
route of adm<strong>in</strong>istration, cost, alteration of flora, or selective pressure <strong>in</strong> an<br />
environment?
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