Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
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PD antibacterial effect of <strong>antimicrobial</strong> agents by<br />
primary bacterial target and by antibiotic class<br />
Primary target Antibacterial class Pharmacodynamics Intracellular<br />
activity<br />
Cell wall<br />
Cell membrane<br />
B-lactams<br />
- penicill<strong>in</strong>s<br />
- cephalospor<strong>in</strong>s<br />
- monobactams<br />
- carbapenems<br />
Glycopeptides<br />
- vancomyc<strong>in</strong><br />
- teicoplan<strong>in</strong><br />
Lipopetides<br />
- Daptomyc<strong>in</strong><br />
Polymyx<strong>in</strong>s<br />
- Polymyx<strong>in</strong> B<br />
- Colist<strong>in</strong><br />
Bactericidal<br />
Time-dependent<br />
PAE only aga<strong>in</strong>st<br />
G(+) organisms<br />
Carbapenems PAE<br />
aga<strong>in</strong>st G(+) & G(-)<br />
organisms<br />
Bactericidal<br />
Concentrationdependent<br />
Long PAE<br />
(Daptomyc<strong>in</strong>)<br />
PAE (polymyx<strong>in</strong>s)<br />
Not generally<br />
effective<br />
Not known
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