Principles in antimicrobial therapy - Pediatric Infectious Disease ...

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Neisseria % Resistance 90 80 70 60 50 40 30 20 10 0 Neisseria gonorrhea Cefixime Ceftriaxone Ciprofloxacin Ofloxacin Penicillin Spectinomycin Tetracycline Number Tested Cefixime Ceftriaxone Ciprofloxacin Ofloxacin Penicillin Spectinomycin Tetracycline Neisseria gonorrhea 0 (75) 0 (82) 47.8 (69) 54.1 (74) 70.7 (75) 0 (70) 81.4 (70)
Step 6. Consider PK/PD properties of drugs • Critical information to guide the selection of both drug and drug dosage in antimicrobial therapy: – 1. route of administration – 2. absorption – 3. tissue distribution of antibiotic at site of infection – 4. drug elimination characteristics
Page 1 and 2: Principles in antimicrobial therapy
Page 3 and 4: Is there anything beyond BE? • Fo
Page 5 and 6: Objectives • 1. Review the basic
Page 7 and 8: Selecting Optimal Antimicrobial The
Page 9 and 10: Acute Otitis Media Macrolides or b-
Page 11 and 12: Step 3. Consider the age of the chi
Page 13 and 14: Step 5. Consider antibiotic suscept
Page 15 and 16: Enteric Patogens 90 80 Percent Resi
Page 17 and 18: Staphlococci and Enterococci % Resi
Page 19: Gram negative, non-fermentative bac
Page 23 and 24: PD antibacterial effect of antimicr
Page 25 and 26: PD antibacterial effect of antimicr
Page 27 and 28: PK/PD basis of optimal antibiotic t
Page 29 and 30: Schematogram of sites of action for
Page 31 and 32: Time vs concentration-dependent ant
Page 33 and 34: Time vs concentration-dependent ant
Page 35 and 36: Time-dependent vs. Concentration-de
Page 37 and 38: Step 7. Consider target attainment
Page 39 and 40: Step 7. Consider target attainment
Page 41 and 42: Step 8. Separate empiric and defini
Page 43 and 44: Step 9. Special considerations •
Page 45 and 46: Take home message • The armamenta

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