Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
Principles in antimicrobial therapy - Pediatric Infectious Disease ...
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Step 6. Consider PK/PD properties of<br />
drugs<br />
• Critical <strong>in</strong>formation to guide the selection of<br />
both drug and drug dosage <strong>in</strong> <strong>antimicrobial</strong><br />
<strong>therapy</strong>:<br />
– 1. route of adm<strong>in</strong>istration<br />
– 2. absorption<br />
– 3. tissue distribution of antibiotic at site of<br />
<strong>in</strong>fection<br />
– 4. drug elim<strong>in</strong>ation characteristics