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Principles in antimicrobial therapy - Pediatric Infectious Disease ...

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Step 7. Consider target atta<strong>in</strong>ment<br />

• In treat<strong>in</strong>g any child, the practitioner must<br />

assess the seriousness of the <strong>in</strong>fection, and<br />

the risk or <strong>in</strong>jury or death if the antibiotic is<br />

not effective.<br />

– Infections that are bothersome (e.g., impetigo)<br />

but non-life-threaten<strong>in</strong>g, a cure rate of 70-80%<br />

with a safe and <strong>in</strong>expensive antibiotic is<br />

acceptable, especially if alternative is us<strong>in</strong>g a drug<br />

with a 98% success rate but has excessive risk of<br />

toxicity or high cost.

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