Selecting and Validating Detergents for CIP Applications- An ... - A3P

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Substrate compatibility• Product contact surfaces should not be reactive,additive, or absorptive to affect safety, quality• Glass and glass lined vessels• Polymers• Metals• Iso-corrosion curves for alkaline cleaners• Gasket materials, EPDM, Teflon, others• Filters, membranes– Stainless steel, rouge, passivation– Soft metals and alloys'(234/++++5$!%%%&
Rinsability of formulated detergents% Removed100.095.090.085.080.075.070.065.060.055.050.045.040.035.030.025.020.015.010.05.00.0TOCSodium (IC)Potassium (IC)TitrationOrganic AcidChelant1530Rinse Time, seconds45
Page 1 and 2: Selecting and Validating Detergents
Page 3 and 4: Selecting cleaning agentsIssues to
Page 5 and 6: Formulated detergentsBroad-spectrum
Page 7 and 8: Cleaning process parameters andfact
Page 9 and 10: Scaling up parameters100Manual Scru
Page 11: CIP cleaningWorst-case locations in
Page 15 and 16: Validating detergentsAcceptance cri
Page 17 and 18: Validating detergentsSampling-Clean
Page 19 and 20: Summary• Factors to consider when

Selecting and Validating Detergents for CIP Applications- An ... - A3P

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