Selecting and Validating Detergents for CIP Applications- An ... - A3P

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Case study- rinsability in a largeprocess10000010000ppm10001001010.1Wash R1 R2 R3 R4ActiveCleaner6*)7)1+/+8!9,%$!%%"&
Validating detergentsAcceptance criteria• Establish limits for cleaning agents andother contaminants– Toxicity based limits for cleaning agents• ADI (acceptable daily intake) based on NOEL (noobservable effect level) or LD 50 values– Other factors such as effect on stability,quality, equipment, or process– Visually clean2:);
Page 1 and 2: Selecting and Validating Detergents
Page 3 and 4: Selecting cleaning agentsIssues to
Page 5 and 6: Formulated detergentsBroad-spectrum
Page 7 and 8: Cleaning process parameters andfact
Page 9 and 10: Scaling up parameters100Manual Scru
Page 11 and 12: CIP cleaningWorst-case locations in
Page 13: Rinsability of formulated detergent
Page 17 and 18: Validating detergentsSampling-Clean
Page 19 and 20: Summary• Factors to consider when

Selecting and Validating Detergents for CIP Applications- An ... - A3P

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