Persistent Pulmonary Hypertension of the Newborn - Mattel ...

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Post-INO Era• Questionnaire to220 neonatologistsin Canada,Australia, NewZealand• High Likelihoodof using othertreatments forPPHNShivananda, 2012
Page 7 and 8: It is 4 AM in the morning -------Yo
Page 9 and 10: Off Label Drug Use• FDA regulates
Page 11: Off Label Drug Use• New uses, dos
Page 16 and 17: Regulation of Pulmonary Vascular To
Page 18: Regulation of Pulmonary Vascular To
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Page 25 and 26: PDE-5 5 Inhibitor - Sildenafil• P
Page 27 and 28: PDE-3 3 Inhibitor - Milrinone• Pr
Page 29 and 30: Milrinone Improves Oxygenationin Ne
Page 31 and 32: Regulation of Pulmonary Vascular To
Page 35: Regulation of Pulmonary Vascular To
Page 38 and 39: In utero exposure to PGSynthetase i
Page 40 and 41: Non-selective action:• Systemic &
Page 42 and 43: PGE 1 - Metabolism70-95%PGE 115-OH
Page 44 and 45: Studies of Inhaled Prostaglandins i
Page 46 and 47: Studies of Inhaled Prostaglandins i
Page 48 and 49: Phase I Clinical Trial of IPGE 1 in
Page 50 and 51: Phase I Trial: Dose ResponseDoseng/
Page 52 and 53: Phase I Trial: Adverse Effects:No e
Page 54 and 55: Effect on Ductus Arteriosus• Echo
Page 56 and 57: Stability and Emitted DoseModified
Page 58 and 59: ResultsLC-MS Chromatograms Followin
Page 60 and 61: Aerosol Particle Size DistributionA
Page 62 and 63:
Pharmacokinetics of IPGE 1 ?
Page 64 and 65:
Nominal DoseAerosolizedRemain in de
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Aerosol Delivery Assessed by MRIExp
Page 68 and 69:
Aerosol Delivery Assessed by MRI450
Page 70 and 71:
Aerosol Delivery During HFOVSood et
Page 72 and 73:
Preliminary Data - Conclusions• P
Page 74 and 75:
Specific AimsPrimary Aims:‣ Evalu
Page 76:
Challenges: RCTs in PPHN• Small n
Page 79 and 80:
Thank YouDiscussion
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