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Persistent Pulmonary Hypertension of the Newborn - Mattel ...

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Regulation <strong>of</strong> <strong>Pulmonary</strong> Vascular ToneBOSENTANEndo<strong>the</strong>lin system in vascular tissueET−1=endo<strong>the</strong>lin−1,BIG–ET−1=proendo<strong>the</strong>lin−1, ECE=endo<strong>the</strong>lin–converting enzyme,NO=nitric oxide, PGI 2 =prostacyclin

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